Lortab is a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid (narcotic) pain medication. Acetaminophen is a less sturdy pain reliever that increases the effect of hydrocodone. Buy Lortab online to treat moderate to severe pain. The ingredient Hydrocodone relieves pain by changing how the brain and nervous system respond to aches.It comes in Lortab 5-325mg, Lortab 7.5-325mg, Lortab 10-325mg.