If you are looking for a safe and effective pain relief medication, you may want to consider Opana ER. Opana ER is a powerful opioid pain medication only available by prescription. This medication is used to treat moderate to severe pain, and it is most often used when other pain medications have not been effective. Opana ER pills are available in both tablet and capsule form, and it should be taken as directed by your doctor. This medication can be taken with or without food; however, it is essential to take it in the same manner each time to ensure consistent results. Opana ER should not be taken more often than prescribed, and it should not be taken for longer than directed.