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Suboxone is an opioid prescription drug used to treat opioid dependence. it contains both Buprenorphine and naloxone. Buprenorphine helps prevent withdrawal symptoms caused by stopping other opioids. It starts to work quickly about 20-60 minutes after the first dose and achieves its maximum effects at around 1 hour 40 minutes. Suboxone can cause mild or severe side effects. Common side effects of Suboxone include headache, diarrhea, constipation, and nausea.