Vicodin 5 mg is a prescription painkiller that contains acetaminophen and hydrocodone. It's used to treat moderate to severe pain, including headaches and Migraines. Vicodin 5 mg (hydrocodone) is a combination of hydrocodone and acetaminophen that's commonly used to treat moderate to severe pain. It's also used to treat cough and severe nausea, as well as for surgery in patients who have had total spinal anesthesia and are unable to move or feel pain.