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Clonazepam and Diazepam are both benzodiazepines used to treat anxiety, seizures, and panic disorders, but clonazepam is generally considered stronger milligram-for-milligram. This means a smaller dose of clonazepam can produce effects similar to or more intense than a larger dose of diazepam. Clonazepam is often preferred for seizure control and panic disorder due to its potency, while diazepam (Valium) is commonly used for anxiety, muscle spasms, and alcohol withdrawal. Although both are long-acting, diazepam has active metabolites that remain in the body longer.

Despite their medical benefits, both medications carry risks of drowsiness, impaired coordination, tolerance, and dependence. Long-term use can lead to physical dependence, and stopping suddenly may cause withdrawal symptoms, including seizures. Misuse or combining either drug with alcohol or opioids significantly increases the risk of respiratory depression and overdose, so they should only be taken under medical supervision.