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Side Effects of Doxycycline and Mental Health Impacts: Antibiotics like doxycycline are trusted tools against infections, but they can sometimes affect more than just bacteria. They may influence mental well-being. While uncommon, some people report anxiety, mood changes, or even depression during treatment. These mental health side effects are rare and not fully understood, but may be linked to doxycycline’s impact on the gut-brain axis or central nervous system. Physical side effects like nausea, sun sensitivity, or headaches are more common. If you experience noticeable mood shifts, don’t stop the medication abruptly. Instead, talk to your doctor. They can help assess your symptoms, adjust treatment if needed, and provide support to ensure your health—both physical and mental stays protected while you heal.