There are many factors to keep in mind when choosing between Office and microsoft365.com/setup Depending on what type of work you want to do on the respective productivity platforms, These software’s are not different in features but in pricing. Microsoft 365 being a subscription-based productivity suite is basically a membership-style program that is better suited for Businesses and Workplaces as there is no need to worry about updates or anything related to custom. Whereas Office is a one-time purchase and does not offer freebies with it. Though as it is a one-time purchase, making it easier to work with and easier to setup up. There is no need for recurring payments and you can use the productivity program as per your need with any of the app that is included with the software. Microsoft Office includes all the premium applications and can be used on any device, ranging from Windows PCs to Mac Book Laptops and Smartphones and tablets.