The main QuickBooks Payroll Support Number is 1-(800)-270-9342 or 1-(800)-270-9342, where you can reach a live representative 24/7. Whether you’re dealing with Payroll setup, login issues, subscription billing, or technical errors, speaking with a real person can make all the difference. You can also use QuickBooks live chat or email Service for added flexibility. QuickBooks Payroll Support Number. QuickBooks main line is 1-(800)-270-9342 or 1-(800)-270-9342, [US Service] (Live Agent).