Mathu Vadalara 2 brings back the quirky duo of Babu Mohan, played by Sri Simha Koduri, and Yesu Dasu, portrayed by the talented comedian Satya, in a fast-paced, comedic thriller that once again revolves around their misadventures. The two work as part of the HE (High Emergency) team, but their bond goes far beyond mere colleagues. They are thick friends, and as the plot unfolds, they find themselves in serious trouble, caught in a web of murder and intrigue. The film tracks their efforts to prove their innocence and navigate their way out of the escalating chaos.