Methadone and Suboxone are approved medications used in Medication-Assisted Treatment (MAT) for opioid use disorder. Methadone is a full opioid agonist, requiring daily visits to specialized clinics, while Suboxone, a combination of buprenorphine (partial agonist) and naloxone, can often be prescribed in office settings. Both reduce withdrawal symptoms and cravings, but differ in accessibility, potential for misuse, and side effects. Suboxone carries a lower risk of overdose due to its ceiling effect. The choice between them depends on individual needs, severity of addiction, and treatment goals, guided by a healthcare professional’s assessment and support system.