Both Oxycodone and Morphine are quite powerful opioid medications with different potencies, durations, and side effects. For example, a large number of individuals often prefer morphine as their first drug of choice to relieve acute pain as well as chronic pain. Oxycodone will relieve pain; the pain may be similar to that relieved by morphine. The drug that is the most useful to you will depend upon several different factors: how bad your pain is, how well you can take either drug, other health problems that you are being treated for, as well as the possible side effects of the drugs that you are taking (drowsiness, constipation, or nausea).