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Ritalin and Vyvanse are both commonly prescribed medications for treating ADHD, but they differ in formulation and duration of effect. Ritalin, a stimulant, works quickly and has a shorter duration, often requiring multiple doses. Vyvanse, a prodrug, is converted in the body and provides a more sustained release throughout the day. While both medications can be effective, individual response and side effects vary, making personalized treatment essential.