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Both Suboxone and Subutex are drugs used to treat opioid dependence, however they differ greatly in order to meet the needs of different patients. The only active ingredient in Subutex is buprenorphine, which reduces cravings and withdrawal symptoms without having the full effects of harsher opioids by partially activating opioid receptors in the brain. In contrast, Suboxone blocks the euphoric effects of opioids in the event that the drug is abused by combining buprenorphine with naloxone, an opioid antagonist.