The Drugs Controller General of India issued notice on convalescent plasma which is used as an off-label investigational therapy of Covid – 19. According to DCGI, it has been informed that Covid – 19 National Taskforce / Joint Monitoring Group of AIIMS/ICMR has gone through and dispensed clinical guidance for managing adult Covid 19 patients wherein " convalescent plasma" is used for investigational therapy as part of the clinical management protocol.